Catalytic mechanism of the colistin resistance protein MCR-1
نویسندگان
چکیده
منابع مشابه
Dissemination and Mechanism for the MCR-1 Colistin Resistance
Polymyxins are the last line of defense against lethal infections caused by multidrug resistant Gram-negative pathogens. Very recently, the use of polymyxins has been greatly challenged by the emergence of the plasmid-borne mobile colistin resistance gene (mcr-1). However, the mechanistic aspects of the MCR-1 colistin resistance are still poorly understood. Here we report the comparative genomi...
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Katrin Zurfluh, Nicolas Kieffer, Laurent Poirel, Patrice Nordmann, Roger Stephan Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, Switzerland; Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland; INSERM European Unit (LEA Paris, France), University of Fribourg, Fribourg, Swi...
متن کاملDeciphering MCR-2 Colistin Resistance
Antibiotic resistance is a prevalent problem in public health worldwide. In general, the carbapenem β-lactam antibiotics are considered a final resort against lethal infections by multidrug-resistant bacteria. Colistin is a cationic polypeptide antibiotic and acts as the last line of defense for treatment of carbapenem-resistant bacteria. Very recently, a new plasmid-borne colistin resistance g...
متن کاملmcr-1 Colistin Resistance in ESBL-Producing Klebsiella pneumoniae, France
We report intestinal carriage of an extended-spectrum β-lactamase-producing Klebsiella pneumoniae strain with high-level resistance to colistin (MIC 24 mg/L) in a patient in France who had been hospitalized for fungal meningitis. The strain had the mcr-1 plasmid gene and an inactivated mgrB gene, which are associated with colistin resistance.
متن کاملAquaculture and mcr Colistin Resistance Determinants
We read with great interest the article in mBio regarding the discovery of a third colistin resistance determinant, mcr-3, in plasmid pWJ1 isolated from porcine Escherichia coli in China (1). This discovery and the subsequently reported discovery of a fourth colistin resistance determinant, mcr-4 (2), provide further support for our hypothesis that the mcr determinants (phosphoethanolamine tran...
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ژورنال
عنوان ژورنال: Organic & Biomolecular Chemistry
سال: 2021
ISSN: 1477-0520,1477-0539
DOI: 10.1039/d0ob02566f